Clear castable polyurethane elastomer for fabrication of microfluidic devices

Clear castable polyurethane elastomer for fabrication of microfluidic devices.

Polydimethylsiloxane (PDMS) has numerous desirable properties for fabricating microfluidic devices, including optical transparency, flexibility, biocompatibility, and fabrication by casting; however, partitioning of small hydrophobic molecules into the bulk of PDMS hinders industrial acceptance of PDMS microfluidic devices for chemical processing and drug development applications. Here we descr...

High-throughput Fabrication of Advanced 3d Microfluidic Devices in Thermoplastic Elastomer for Biological Probe Immobilization

We have developed a process based on hot-embossing lithography (HEL) to pattern at high-throughput micron-size through-holes in thin thermoplastic elastomer (TPE) membranes. This novel HEL process, which is shown to provide key advantages for microfluidics applications, was applied to the fabrication of highly-integrated 3D microfluidic devices designed to precisely immobilize biomolecules on t...

Nonlithographic fabrication of microfluidic devices.

A facile nonlithographic method for expedient fabrication of microfluidic devices of poly(dimethylsiloxane) is described. Positive-relief masters for the molds are directly printed on smooth substrates. For the formation of connecting channels and chambers inside the polymer components of the microfluidic devices, cavity-forming elements are adhered to the surfaces of the masters. Using this no...

Microfluidic Devices Fabrication for Bioelectrokinetic System Applications

Fabrication of microfluidic devices using polydimethylsiloxane.

Polydimethylsiloxane (PDMS) is nearly ubiquitous in microfluidic devices, being easy to work with, economical, and transparent. A detailed protocol is provided here for using PDMS in the fabrication of microfluidic devices to aid those interested in using the material in their work, with information on the many potential ways the material may be used for novel devices.